Fed up with her parents' bickering, poor-little-rich-girl Maya (Dylan Penn) moves in with her boyfriend who is squatting in an old, condemned building on Manhattan's Lower East Side. With neighbors that are meth heads, junkies and degenerates, this depraved hell hole is even more toxic than it appears: After a virus born from their combined noxious waste and garbage infects the building's residents, one by one, they succumb to a terrifying pathogen that turns them into bloodthirsty, rampaging killers and transforms their building into a savage slaughterhouse.

When Mickey's crazy step-son Leon is killed in a construction 'accident', nobody in the working class neighborhood of God's Pocket is sorry he's gone. Mickey tries to bury the bad news with the body, but when the boy's mother demands the truth, Mickey finds himself stuck in a life-and-death struggle between a body he can't bury, a wife he can't please and a debt he can't pay.

It's early autumn of 1975 in Brooklyn and 18-year-old Brian Leary (Nick Thurston) is killing time, pulling off petty crimes with his street tough older brother Danny (Geoff Wigdor), whom he both idolizes and fears. He doesn't really want to be a criminal, but he doesn't share the dreams of his old friends from their working class neighborhood either. They all yearn for the culturally approved 9-to-5 Civil Service jobs with benefit packages that will carry them through weekends of beer into lazy retirement. Brian doesn't want to end up in a soul-numbing job like his buddies, but he's sure he doesn't want to be like his best friend Todd (Zachary Booth) either. Todd has betrayed their blue-collar roots by accepting a scholarship to college. But Brian has a secret -- he's a talented artist. In the basement of the bagel shop beneath his parent's apartment...